Topiramate (USAN: Topiramate) is a drug used to treat certain types of epilepsy and migraine headaches. It is also used to prevent migraine headaches in certain patients. It is a second-generation anticonvulsant that is structurally related to valproic acid. It is available as a generic drug in the United States and in many other countries. It is marketed under the brand name Topamax. It is a white or off-white crystalline substance that is freely soluble in water, but practically insoluble in alcohol and soluble in acetone, ether, and chloroform.
It is sold as a tablet with a sugar coating for oral administration. Topiramate is a medication that may be given with other drugs. It is best administered on an empty stomach.
Sometimes some people have difficulty swallowing Topiramate. For some people, Topiramate can cause more side effects than other antiepileptic drugs. It should not be used by people with a history of liver disease. If liver problems occur, it is important that Topiramate is stopped. The health problems that are more likely to occur when Topiramate is used include:
gastrointestinal problems (especially nausea and diarrhea)
anemia (due to iron loss from the intestines)
Topiramate is a “sucrose-free” version of this drug that is available in powder form. Before taking Topiramate, your doctor will check a test to see how your body reacts to this drug. This is called a “pregnancy check”.
Alternatives to Topiramate: Topiramate may not be the best option for everyone. If this is the case, a trial and error approach may be used to find a medication that works best for your individual needs. There are alternative medications that are used to treat epilepsy, such as Valproic acid (Depakote) or Phenobarbital. Sometimes people with epilepsy are treated with medications that have no specific effects on the brain. This is known as “polytherapy”.
There are also medications that have a different mechanism of action, such as the old school medication Zonisamide. This medication is effective for some people. However, it has certain side effects that limit its use, such as being often used in younger patients.
The vast majority of antiepileptic drugs are used for treating partial seizures. However, Topiramate
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Michael Cohen was today sentenced to three years in prison and fined $50,000 by a Manhattan federal judge after pleading guilty to eight felonies.
Federal prosecutors had recommended a prison term of under 24 months but Judge William Pauley said this was wrong and handed down a sentence three times greater.
After Mr Cohen, 52, the former lawyer to President Donald Trump, pleaded guilty to conspiring to make false statements, obstructing justice and a litany of other charges, his lawyers said he would not appeal.
He admitted making and using a fake, and perhaps illegal, invoices to pay off Trump’s accusers shortly before the 2016 election.
Cohen’s crimes that led to today’s harsh sentence
Cohen was sentenced to three years and handed a fine of $50,000
Cohen paid Stormy Daniels $130,000 in hush money
He failed to fully disclose to Congress that he had paid off women who claimed they had affairs with Mr Trump
He ran his own failed Trump Organisation clothing business while still undertaking secret but ethically dubious work for Mr Trump